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| c. 1850 |
| | | The Scottish missionary David Livingstone is profoundly shocked by what he sees of the slave trade at the heart of Africa | |
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| 1850 |
| | | The British government buys the Danish fortresses on the Gold Coast, including Christiansborg castle in Accra | |
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| 1850 |
| | | Brazil, historically the world's second largest importer of slaves from Africa, finally bans the slave trade | |
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| 1853 |
| | | David Livingstone makes a heroic six-month journey from the Zambezi river to the west coast of Africa | |
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| 1854 |
| | | The Boers establish the Orange Free State as an independent republic, with its own custom-built constitution | |
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| 1854 |
| | | William Baikie, on an expedition up the Niger, protects his men from malaria by administering quinine | |
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| 1854 |
| | | Ferdinand de Lesseps is granted the concession to construct a canal from the Mediterranean to the Red Sea | |
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| 1855 |
| | | An Ethiopian baron usurps the throne and proclaims himself emperor, as Theodore II | |
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| 1857 |
| | | David Livingstone urges upon a Cambridge audience the high ideal of taking 'commerce and Christianity' into Africa | |
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| 1857 |
| | | The Boers of the southern Transvaal declare independence as the South African Republic | |
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